The Reactome molecule Event page
provides a detailed description of each
molecule that participates in a Reactome reaction. This description
includes
(where applicable) a link to its sequence, links to the corresponding
molecule
in other databases (ie: Ensemble and Locus Link, ChEBI), the Reference
entity
(i.e. Reactome's reference database identifier), the subcellular
location at
which molecule is functioning, the organism in which the molecule
functions, a
list of any Reactome complexes that include the molecule, and a list of
processes within Reactome in which the entity had been shown to be
involved. In
addition, all Reactome reactions in which the molecule takes part will
be
highlighted in the Reaction Map. The reaction arrows are color
coded to
describe the role of the given molecule in the reaction. Red indicates
that the
molecule functions as an input in the reaction, Green = output,
Yellow =
both input and output, Blue = catalyst and Violet = input and catalyst.
A description
of human Cdc2 is shown below (the "participates in process"
section has been truncated for viewing purposes):
Here, one can further click to
access the 'Reference Entity' page for this molecule. This provides
(a)details as to the various synonyms by which the molecule is known,
(b) external links to established reference databases with information
on this entity, and, (c) if it is a "small molecule", a chemical
fingerprint of the molecule. The chemical fingerprint describes the
type and number of chemical groups that this molecule contains. An
example of a fingerprint for ATP is shown below:
Every small molecule in Reactome has
a verified structure file (in MOL format) that is 'fingerprinted' by a set
of molecular groups. Clicking
on any of the group names in
the above Chemical fingerprint generates a list of all small molecules
in Reactome that contain this substructure.
The set of chemical groups used in this fingerprinting procedure will expand in parallel with
our process annotations to maintain an adequate descriptive level of those
structures involved in our reactions. Complexes are also described on separate pages.
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